Why we need probiotics

 

The intestines and stomach are vulnerable

Custom of eating together

Easier access to harmful bacteria

Much oil, salt and sugar

Sedentary behavior and obesity

Irregular daily routine

Anxieties difficult urinationand defecation

Over refined diet

Not enough dietary fiber

 

The importance of intestinal health

More than 70 percent of the body’s immune cells are in the intestinal tract

The intestinal tract is familiar but distinct to us. We all know that it is an organ for digesting food and absorbing nutrients, but we are unfamiliar with the fact that it is more than that. To solve the increasing common health problems of modern people, we must first solve intestinal health problems.

In recent years, with the application and development of metagenomics, macrotranscriptomics, metabolomics and other technologies, a large number of researches have begun to explore the relationship between the composition, structure and function of intestinal flora and body conditions.

 

What role do probiotics play in intestinal health?

The human gastrointestinal tract is inhabited by a large number and variety of microbes, which are collectively known as intestinal flora. They are usually classified as the good, the bad and the neutral in terms of their effects on the body.

Under normal circumstances, intestinal flora maintain a symbiotic or antagonistic relationship with each other to achieve balance. However, when the number of harmful bacteria increases or the number of probiotics decreases, the probiotics are not enough to restrain the harm of harmful bacteria to the body，then people will suffer from various diseases.

Food and Agriculture Organization of the United Nations(FAO)
World Health Organization (WHO) ‘s definition of probiotics:

Probiotics are live microorganisms, and when ingested sufficiently, it is beneficial for health.

Probiotics are not just one or several kinds of bacteria. It’s a general term for a group of bacteria that are good for human health.
At present, there are dozens of probiotics that have been found, including Bifidobacterium animalis subsp.lactis,Lactobacillus acidophilus,Bifidobacterium longum subsp. infantis,Lacticaseibacillus casei and so on.
In developed countries, the amount of probiotics in the body has been an indicator of health.

 

Why we need to take in extra probiotics
besides the original ones in the body?

The proportion of probiotics in relation to age

·Chronic diarrhea       ·Long-term use of drugs       ·High stress       ·Lack of sleep       

·Irregular meal timings       ·Lack of exercise       ·Normal bacterial metabolism       

······  Unconsciously, probiotics slip away from the body

 

Keeping alive before reaching the intestine
is the premise for probiotics to function

The place where probiotics function is mainly in the lower gastrointestinal tract. However, stomach acid and bile salt in the intestine will devitalize the weak-tolerant probiotics, almost unable to survive to reach the intestine. Resisting the erosion of various digestive juices, so as to reach the intestine viably, and adhering to the intestinal wall, all of which are the premise of probiotics to work. Therefore, it is of great significance to select the excellent strains that are resistant to gastric acid and bile salt in the small intestine.

 

Adhesion colonization is the key for
probiotics to function

An important mechanism of probiotics is that they compete with harmful bacteria for the adhesion site of the intestinal wall, and only after adhesion can they stabilize colonization to reproduce the bacteria and thus exert their probiotic effect. Therefore, the adhesion ability of probiotics is a key factor for their colonization in the intestinal tract, which is also an import ant standard for strain quality detection and selection.

If probiotics can’t colonize in the intestinal tract but are excreted during digestion, the consumption will be useless. Therefore, when choosing high-quality probiotics, we must pay attention to whether they can adhere and colonize.

 

What is the mystery of probiotic
strain combinations?

In the complex environment of the intestines and stomach, different types of probiotics have different optimal function sites, therefore, through scientific collocation of strains, probiotics can colonize in different parts intestines and stomach according to their respective advantages, so that the stomach can get more comprehensive and targeted care.

 

These are not probiotics!

-巴氏灭菌的灭活乳酸菌产品
-以死亡细菌为基础的日用化学品
-微生物含量不确定的发酵食品

 

把心思放在六个特点上
选择优质益生菌

安全

菌株应通过全基因组测序，无已知风险基因，无获得性抗生素耐药性，并获得国内和国际权威机构的认证。

稳定性

菌种均有菌种名称、菌种编号和保藏编号，以确保菌种特性的稳定性，实现全程可追溯。

有效性

我们从细胞层面对菌株进行了培养和筛选，并通过了胃肠道模拟试验、体外和动物试验、人体临床试验等多重功效测试，拥有相当数量的相关研究文献。

精度

我们精确测量胃肠中菌株的需求量，通过科学匹配，实现优秀菌株的高效协作和胃肠道的全覆盖。

有效性

它需要通过胃酸和胆盐耐受性的测试；能够承受人体复杂的胃肠道环境，并在胃肠道中保持极佳的存活率。
睾丸道。

殖民化

菌株应与人体肠道细胞和结肠粘液具有良好的粘附性，并能在胃肠道内持久定植，在体内形成相对稳定的肠道健康菌群。

 

 

阳谷温-养护肠道
每 "益生菌" 天

SIJIYOUMEI
近十年来
胃肠道护理智慧
以更平易近人的方式
确定新内涵
为您带来健康生活

低温冷冻干燥
活菌可直接进入肠道

净重 40 克（2 克 X20）           保质期： 18 个月           味道 葡萄柚、柠檬
储存条件 请在室温（不高于 25°C）下干燥保存，冷藏效果更好。

 

九大优势
护理肠道

ATCC 保藏号：Lactobacillus acidophilus NCFM（SD-5221）、Bifidobacterium animalis subsp. lactis B420（SD-6685）、Bifidobacterium animalis subsp.Bi-07（SD-5220）、动物双歧杆菌亚种 Bl-04（SD-5219）、副乳酸杆菌 Lpc-37（SD-5275）

2.在生产过程中，每片都添加了≥200 亿 CFU 的活性益生菌。

3.数据来自供应商的内部实验室。2022.10.26批次的阳谷温益生菌产品样品在人体胃肠道模拟环境模拟实验中，耐胃酸率为94%，耐胆盐率为95%。该产品在实际储运过程中，由于环境不同
因此，测试数据可能会存在一些差异。

 

通过优势生产线
质量更有保证

所有菌株均由全球公认的、拥有 100 多年历史的益生菌标杆企业定制。
真正的研发力量！

采用世界领先的益生菌生产线，内置自动传感器和监控系统，无需人工取样，有助于菌种保持最佳生长条件。发酵液采用压缩空气技术混合，避免了传统泵和搅拌叶片对菌种的破坏。独特的超低温冷冻干燥技术可保持细胞膜的完整性，长期保持菌种活性。高浓缩粉末可严格控制水活性，确保菌种的稳定性。

 

核实菌株来源至关重要

严格的应变发展程序：

应以基因组学为基础研究益生菌菌株的安全性

*Yang Gu Wen probiotic strains

 

Enough convincing scientific literature support

967 public researches, including 288 in human clinical researches.

· In vitro and animal tests
· Clinical tests on different population
· Single strain and strain combination clinical tests
· Low dose and high dose tests

The clinical tests of Yang Gu Wen probiotic strains were designed and carried out according to the international clinical research quality standards provided by the International Conference on Coordination (ICH), and went through different stages including infants, children, adults and the elderly. The supplemental dose varies from low to high, and the supplemental period varies from 1 week to 1 year.

 

The strains selected for the
Yang Gu Wen probiotics have been
evaluated by international authorities.

Lactobacillus acidophilus NCFM, Bifidobacterium animalis subsp. lactis B420, Bifidobacterium animalis subsp. lactis Bi-07, Lacticaseibacillus paracasei Lpc-37 and Bifidobacterium animalis subsp. lactis Bl-04 adopted by the Yang Gu Wen probiotics have all passed the European EFSA QPS certification and are listed in The List of Bacteria Available for Food issued by the National Health Commission. All the strains were GRAS certified by FDA, and 2 of them were included in The List of Bacteria Available for Food issued by the National Health Commission.

 

Each of the strains selected
has a deposit number

· We have stored the standard strain in the USA ATCC cryogenic strain repository.

· Before each use, the identity of the strain will be confirmed by DNA fingerprint to ensure 100% match.

· The number of generations used is controlled within 2

Ensure the quality, purity and gene consistency

 

Full vitality to protect the intestine

94% The live bacteria can reach the intestine directly.

In IFF simulated human environment test, the stomach acid and bile salt tolerance rates of Yang Gu Wen probiotics are 94% and 95%, respectively.

Strong adhesion and colonization

The adhesion to the intestinal mucosa determines how long the probiotic strains live in the intestine. Rigorous in vitro tests have proved that the five strains of probiotics selected by the Yang Gu Wen have excellent adhesion to human intestinal cells and colon mucus.

 

Are the more varieties and amount of probiotics the better?
NO!

For star strength”bacteria” group, five types with 20 billion CFU, that is enough!

SIJIYOUMEI “Yang Gu Wen” cooperated with the global benchmarking probiotic R&D team, * through nearly 10,000 groups of experimental data analysis:

The scientific combination of Lactobacillus acidophilus NCFM, Bifidobacterium animalis subsp. lactis B420, Bifidobacterium animalis subsp. lactis Bi-07, Lacticaseibacillus paracasei Lpc-37 and Bifidobacterium animalis subsp. lactis Bl-04can produce an efficient synergic effect, each of which has an added amount of 20 billion CFU. Therefore, while beneficial to health, it will not cause unnecessary burden or waste to the intestinal tract.

*The team has participated in the revision of the industry standard “Lactic Acid Bacteria for Food Processing”, the group standard “Classification Code for Viable Bacteria Rate of Probiotic Food” and “General Principles of Probiotics for Food”

 

⸺Restore

A compound probiotic formula that can quickly restore intestinal vitality

Restore compound probiotic formula is a breakthrough research achievement in the field of probiotics, which has special contribution and significance in the history of probiotics research and development. So far, it is one of the few formulas that have been tested in clinical researches in China based on a combination of four strains. Researches have shown that the Restore formula can help restore intestinal vitality quickly, making it a worthy “chief protector of intestinal tract health.” The formula was applied to the Yang Gu Wen probiotics, which greatly enhanced the strength of the probiotics to protect the intestinal tract.

Lactobacillus acidophilus NCFM
「Make the stomach more comfortable」

Bifidobacterium animalis subsp. lactis Bi-07
「The stomach is no longer upset」

Bifidobacterium animalis subsp. lactis Bl-04
「The constitution is quietly enhanced」

Lacticaseibacillus paracasei Lpc-37
「Relieve stress and help growth」

Bifidobacterium animalis subsp. lactis B420
「Star strain for weight management」

 

7 pieces of prebiotics
Feed the strain and it will be more energetic!