Why we need probiotics

 

The intestines and stomach are vulnerable

Custom of eating together

Easier access to harmful bacteria

Much oil, salt and sugar

Sedentary behavior and obesity

Irregular daily routine

Anxieties difficult urinationand defecation

Over refined diet

Not enough dietary fiber

 

The importance of intestinal health

More than 70 percent of the body’s immune cells are in the intestinal tract

The intestinal tract is familiar but distinct to us. We all know that it is an organ for digesting food and absorbing nutrients, but we are unfamiliar with the fact that it is more than that. To solve the increasing common health problems of modern people, we must first solve intestinal health problems.

In recent years, with the application and development of metagenomics, macrotranscriptomics, metabolomics and other technologies, a large number of researches have begun to explore the relationship between the composition, structure and function of intestinal flora and body conditions.

 

What role do probiotics play in intestinal health?

The human gastrointestinal tract is inhabited by a large number and variety of microbes, which are collectively known as intestinal flora. They are usually classified as the good, the bad and the neutral in terms of their effects on the body.

Under normal circumstances, intestinal flora maintain a symbiotic or antagonistic relationship with each other to achieve balance. However, when the number of harmful bacteria increases or the number of probiotics decreases, the probiotics are not enough to restrain the harm of harmful bacteria to the body，then people will suffer from various diseases.

Food and Agriculture Organization of the United Nations(FAO)
World Health Organization (WHO) ‘s definition of probiotics:

Probiotics are live microorganisms, and when ingested sufficiently, it is beneficial for health.

Probiotics are not just one or several kinds of bacteria. It’s a general term for a group of bacteria that are good for human health.
At present, there are dozens of probiotics that have been found, including Bifidobacterium animalis subsp.lactis,Lactobacillus acidophilus,Bifidobacterium longum subsp. infantis,Lacticaseibacillus casei and so on.
In developed countries, the amount of probiotics in the body has been an indicator of health.

 

Why we need to take in extra probiotics
besides the original ones in the body?

The proportion of probiotics in relation to age

·Chronic diarrhea       ·Long-term use of drugs       ·High stress       ·Lack of sleep       

·Irregular meal timings       ·Lack of exercise       ·Normal bacterial metabolism       

······  Unconsciously, probiotics slip away from the body

 

Keeping alive before reaching the intestine
is the premise for probiotics to function

The place where probiotics function is mainly in the lower gastrointestinal tract. However, stomach acid and bile salt in the intestine will devitalize the weak-tolerant probiotics, almost unable to survive to reach the intestine. Resisting the erosion of various digestive juices, so as to reach the intestine viably, and adhering to the intestinal wall, all of which are the premise of probiotics to work. Therefore, it is of great significance to select the excellent strains that are resistant to gastric acid and bile salt in the small intestine.

 

Adhesion colonization is the key for
probiotics to function

An important mechanism of probiotics is that they compete with harmful bacteria for the adhesion site of the intestinal wall, and only after adhesion can they stabilize colonization to reproduce the bacteria and thus exert their probiotic effect. Therefore, the adhesion ability of probiotics is a key factor for their colonization in the intestinal tract, which is also an import ant standard for strain quality detection and selection.

If probiotics can’t colonize in the intestinal tract but are excreted during digestion, the consumption will be useless. Therefore, when choosing high-quality probiotics, we must pay attention to whether they can adhere and colonize.

 

What is the mystery of probiotic
strain combinations?

In the complex environment of the intestines and stomach, different types of probiotics have different optimal function sites, therefore, through scientific collocation of strains, probiotics can colonize in different parts intestines and stomach according to their respective advantages, so that the stomach can get more comprehensive and targeted care.

 

These are not probiotics!

·Pasteurized, inactivated lactobacillus products
·Daily chemicals based on dead bacteria
·Fermented foods with uncertain microbial

 

Set your mind on the six characteristics
Choose probiotics with good quality

Safety

The strains should have passed the whole genome sequencing,without known risk genes, without acquired antibiotic resistance, and should be certified by domestic and international authorities.

Stability

The strains all have the strain name, strain number and deposit number, so as to ensure the stability of the strain characteristics, and achieve full traceability.

Effectiveness

We have conducted culture and selection of the strain from the cellular level, and have passed multiple effectiveness tests such as gastrointestinal simulation test, in vitro and animal test, and human clinical trial, and have a considerable number of relevant research literature.

Precision

We accurately measure the demand of strains in the stomach and intestines, and achieve efficient collaboration of excellent strains and full coverage of the gastrointestinal tract through scientific matching.

Liveness

It needs to pass the test of stomach acid and bile salttolerance; can withstand the complex gastrointestinal environment of the human body,and maintain excellent survival rate in the gastroin-
testinal tract.

Colonization

The strain should have excellent adhesion to human intestinal cells and colon mucus, and can colonize in the gastrointestinal tract efficiently, to form a relatively stable intestinal healthy flora in the body.

 

 

Yang Gu Wen-Maintenance of intestinal tract
every “probiotics” day

SIJIYOUMEI
With nearly ten years of
gastrointestinal nursing wisdom
In a more approachable way
Define the new connotation
of healthy life for you

Freezing drying under low temperature
Live bacteria can reach the intestine directly

Net weight: 40g (2gX20)           Haltbarkeitsdauer: 18 Monate           Taste: Grapefruit、Lemon
Storage conditions: Please store at room temperature (not higher than 25°C), in dry place, cold storage is better.

 

Nine Advantages
Care for the intestinal tract

1. ATCC deposit number：Lactobacillus acidophilus NCFM（SD-5221）、Bifidobacterium animalis subsp. lactis B420（SD-6685）、 Bifidobacterium animalis subsp. lactis Bi-07（SD-5220）、Bifidobacterium animalis subsp. lactis Bl-04（SD-5219）、Lacticaseibacillus paracasei Lpc-37（SD-5275）

2. Active probiotics ≥20 billion CFU are added to each piece during production.

3. The data came from the supplier’s internal laboratory. The 2022.10.26 batches of the Yang Gu Wen probiotic product samples showed a stomach acid resistance rate of 94% and bile salt resistance rate of 95% in the simulated environment experiment of human gastrointestinal tract. During the actual storage and transportation of this product, due to different environmental
conditions, there may be some differences in the test data.

 

By advantage production line
quality is more guaranteed

All strains are customized by globally recognized probiotic benchmarking enterprises with a history of more than 100 years.
The real research and development power!

With the world’s leading probiotic production line, built-in automatic sensor and monitor system, there is no manual sampling, which helps strains to maintain the optimal growth conditions. The fermentation solution was mixed by compressed air technology to avoid the traditional pump and stirring blade to destroy the bacteria. The unique ultra low temperature freeze-drying technology can maintain the intactness of cell membrane and keep the activity of strain for a long time. The highly concentrated powder can strictly control the water activity to ensure the stability of the strain.

 

Verification of the source of the strain is critical

Rigorous strain development procedure:

Researches on the safety of probiotic strains should be based on genomics

*Yang Gu Wen probiotic strains

 

Enough convincing scientific literature support

967 public researches, including 288 in human clinical researches.

· In vitro and animal tests
· Clinical tests on different population
· Single strain and strain combination clinical tests
· Low dose and high dose tests

The clinical tests of Yang Gu Wen probiotic strains were designed and carried out according to the international clinical research quality standards provided by the International Conference on Coordination (ICH), and went through different stages including infants, children, adults and the elderly. The supplemental dose varies from low to high, and the supplemental period varies from 1 week to 1 year.

 

The strains selected for the
Yang Gu Wen probiotics have been
evaluated by international authorities.

Lactobacillus acidophilus NCFM, Bifidobacterium animalis subsp. lactis B420, Bifidobacterium animalis subsp. lactis Bi-07, Lacticaseibacillus paracasei Lpc-37 and Bifidobacterium animalis subsp. lactis Bl-04 adopted by the Yang Gu Wen probiotics have all passed the European EFSA QPS certification and are listed in The List of Bacteria Available for Food issued by the National Health Commission. All the strains were GRAS certified by FDA, and 2 of them were included in The List of Bacteria Available for Food issued by the National Health Commission.

 

Each of the strains selected
has a deposit number

· We have stored the standard strain in the USA ATCC cryogenic strain repository.

· Before each use, the identity of the strain will be confirmed by DNA fingerprint to ensure 100% match.

· The number of generations used is controlled within 2

Ensure the quality, purity and gene consistency

 

Full vitality to protect the intestine

94% The live bacteria can reach the intestine directly.

In IFF simulated human environment test, the stomach acid and bile salt tolerance rates of Yang Gu Wen probiotics are 94% and 95%, respectively.

Strong adhesion and colonization

The adhesion to the intestinal mucosa determines how long the probiotic strains live in the intestine. Rigorous in vitro tests have proved that the five strains of probiotics selected by the Yang Gu Wen have excellent adhesion to human intestinal cells and colon mucus.

 

Are the more varieties and amount of probiotics the better?
NO!

For star strength”bacteria” group, five types with 20 billion CFU, that is enough!

SIJIYOUMEI “Yang Gu Wen” cooperated with the global benchmarking probiotic R&D team, * through nearly 10,000 groups of experimental data analysis:

The scientific combination of Lactobacillus acidophilus NCFM, Bifidobacterium animalis subsp. lactis B420, Bifidobacterium animalis subsp. lactis Bi-07, Lacticaseibacillus paracasei Lpc-37 and Bifidobacterium animalis subsp. lactis Bl-04can produce an efficient synergic effect, each of which has an added amount of 20 billion CFU. Therefore, while beneficial to health, it will not cause unnecessary burden or waste to the intestinal tract.

*The team has participated in the revision of the industry standard “Lactic Acid Bacteria for Food Processing”, the group standard “Classification Code for Viable Bacteria Rate of Probiotic Food” and “General Principles of Probiotics for Food”

 

⸺Restore

A compound probiotic formula that can quickly restore intestinal vitality

Restore compound probiotic formula is a breakthrough research achievement in the field of probiotics, which has special contribution and significance in the history of probiotics research and development. So far, it is one of the few formulas that have been tested in clinical researches in China based on a combination of four strains. Researches have shown that the Restore formula can help restore intestinal vitality quickly, making it a worthy “chief protector of intestinal tract health.” The formula was applied to the Yang Gu Wen probiotics, which greatly enhanced the strength of the probiotics to protect the intestinal tract.

Lactobacillus acidophilus NCFM
「Make the stomach more comfortable」

Bifidobacterium animalis subsp. lactis Bi-07
「The stomach is no longer upset」

Bifidobacterium animalis subsp. lactis Bl-04
「The constitution is quietly enhanced」

Lacticaseibacillus paracasei Lpc-37
「Relieve stress and help growth」

Bifidobacterium animalis subsp. lactis B420
「Star strain for weight management」

 

7 pieces of prebiotics
Feed the strain and it will be more energetic!